First Report of Smut Caused by Microbotryum silybum on Ivory Thistle

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Milk Thistle (Silybum marianum)

Milk thistle is a well known and commonly used herb, used particularly in hepatic diseases. It has very potent antioxidant, anti-inflammatory, and antifibrotic properties (1). As a single agent its therapeutic effects in liver disease appear to be modest (2,3,4,5). Herbal medicines and supplements are likely to be much more beneficial when used synergistically in combinations or formulas. Milk ...

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Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan.

PURPOSE Milk thistle (Silybum marianum) is one of the most commonly used herbal therapies, and its principal constituent silybin significantly inhibits cytochrome P450 isoform 3A4 (CYP3A4) and UDP glucuronosyltransferase isoform 1A1 (UGT1A1) in vitro. Here, we investigated whether milk thistle affects the pharmacokinetics of irinotecan, a substrate for CYP3A4 and UGT1A1, in humans. EXPERIMENT...

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Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.

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ژورنال

عنوان ژورنال: Plant Disease

سال: 2005

ISSN: 0191-2917,1943-7692

DOI: 10.1094/pd-89-1242a